| Diebold Nixdorf | North Canton | 1859 |
| Digital Eclipse | California | 7 de agosto de 1992 |
| Digital Realty | Austin | 2004 |
| Diners Club | Riverwoods | 1950 |
| Dish | Meridian | 1996 |
| Disney Games Group | Glendale | 1994 |
| Disney Streaming | Nueva York | 13 de agosto de 2015 |
| Disney Television Animation | Glendale | 5 de diciembre de 1984 |
| Docusign | San Francisco | 2003 |
| Dodge | Dodge Building | 14 de diciembre de 1900 |
| Dollar General | Goodlettsville | 1939 |
| Domino's Pizza | Domino's Farms, Municipio de Ann Arbor | 1960 |
| Dover Corporation | Downers Grove | 1955 |
| Dr Pepper Snapple Group | Plano | 7 de mayo de 2008 |
| Dr. Scholl's | Chicago, Londres | 1906 |
| Dremel | Racine | 1932 |
| Duke Energy | Charlotte | 1997 |
| Dunkin' Brands | Canton | 1950 |
| Duracell | Chicago, Bethel | 1930 |
| DYMO Corporation | Berkeley | 1958 |
| E-ZPass | Wilmington | 1987 |
| E. Remington and Sons | Estados Unidos | 1816 |
| EA Sports | Burnaby | 1991 |
| Eaton Corporation | Cleveland | 1911 |
| Eazel | Mountain View | 1999 |
| EBSCO Information Services | Birmingham | 1943 |
| EchoStar | Englewood | 1980 |
| Ecolab | Saint Paul | 1923 |
| Electronic Industries Alliance | condado de Arlington | 1924 |
| Elevance Health | Indianápolis | 2004 |
| EMG | Santa Rosa | 1976 |
| Endeavor Group Holdings | Beverly Hills | 1898 |
| Energy Transfer Partners | Dallas | 1996 |
| Enron | Houston | 1985 |
| Enstrom Helicopter Corporation | Menominee | 1959 |
| Enterprise Products | Houston | 1968 |
| EnterpriseDB | Bedford | marzo 2004 |
| Epicor | Austin, Irvine | 1972 |
| Equifax | Atlanta | 1899 |
| ESPN+ | Estados Unidos | 12 de abril de 2018 |
| Ethyl Corporation | Richmond | 1921 |
| Etsy | DUMBO, Nueva York, Brooklyn | 18 de junio de 2005 |
| Euronet Worldwide | Leawood | 1994 |
| Everlast | Nueva York | 1910 |
| Exelon Corporation | Chicago | 2000 |
| Expeditors International | Seattle | 1979 |
| Exxon | Las Colinas | 1 de enero de 1973 |
| FactSet Research Systems | Norwalk | 1978 |