| Bechtel | Reston | 1906 |
| Beckman Coulter | Krefeld, Brea | 1935 |
| Bell Telephone Company | — | 9 de julio de 1877 |
| Bellator MMA | Newport Beach | 2008 |
| Ben & Jerry's | South Burlington | 1978 |
| Benchmark | Menlo Park | 1995 |
| Bergdorf Goodman | Nueva York | 1929 |
| Best Buy | Richfield | 22 de agosto de 1966 |
| Best Western Hotels & Resorts | Phoenix | 1946 |
| Beyond Meat | El Segundo | 2009 |
| BFG Technologies | Lake Forest | 2002 |
| Bigelow Aerospace | North Las Vegas | 1999 |
| Bio-Rad Laboratories | Hercules | 1952 |
| Bitly | Nueva York | 2008 |
| Bitstream Inc. | Cambridge, Marlborough | 1981 |
| BlackRock | Nueva York | 1988 |
| Blackstone Group | Nueva York | 1985 |
| Blinding Edge Pictures | Berwyn | 1999 |
| Blockbuster Inc. | Dallas | 1985 |
| Bloomberg L.P. | Nueva York, Bloomberg Tower | 1 de octubre de 1981 |
| Blu Products | Doral, Paramount | 2009 |
| Bluehost | Provo | 2022 |
| BlueStacks | Campbell | 2011 |
| BMC Software | Houston | 1980 |
| BMG Rights Management | Quartier 205 | 1 de octubre de 2008 |
| Bobcat | West Fargo | 1947 |
| Booking Holdings | Norwalk | julio 1997 |
| Booz Allen Hamilton | Tysons | 1914 |
| Borders | Ann Arbor | 1971 |
| Boston Dynamics | Waltham | 6 de noviembre de 1992 |
| Box | Redwood City | mayo 2009 |
| Box Office Mojo | — | 1999 |
| Braum's | Oklahoma City | 1968 |
| Brink's | condado de Henrico | 1859 |
| Brocade Communications Systems | San José | 1995 |
| Brooklyn-Manhattan Transit Corporation | Brooklyn | 1923 |
| Brooks Brothers | Nueva York | 1818 |
| Brown & Williamson | Louisville | 1894 |
| Browning Arms Company | Morgan | 1927 |
| Bucyrus international | South Milwaukee | 1880 |
| Build-A-Bear Workshop | San Luis | 1997 |
| Bulova | Nueva York | 1875 |
| Bunge Limited | Hamilton, White Plains | 1818 |
| Burger Chef | Indianápolis | 1954 |
| Burlington | Municipio de Florence | 1972 |
| Burroughs Corporation | Detroit, Misuri, San Luis | 1904 |
| Bushmaster Firearms International | Madison | 1973 |
| BuzzFeed | Nueva York, Nueva York | 2006 |