| Prime Computer | Natick | 1972 |
| Prince Sports | Bordentown | 1970 |
| Principal Financial Group | Des Moines | 1879 |
| Professional Fighters League | Área metropolitana de Las Vegas | 2012 |
| PRS Guitars | Stevensville | 1985 |
| Prudential Financial | Sede de Prudential | 1875 |
| Pullman Co | Chicago, Denver | 1927 |
| Pyra Labs | San Francisco | 1999 |
| Qlikview | King of Prussia | 1993 |
| Qorvo | Greensboro | 2015 |
| Quora | Mountain View | 21 de junio de 2010 |
| R. J. Reynolds Tobacco Company | Winston-Salem | 1874 |
| Radisson Hotel Group | Minnetonka | 1962 |
| Rainforest Cafe | Houston | 1994 |
| Raytheon Technologies Corporation | condado de Arlington | 3 de abril de 2020 |
| Razer Inc. | George Town, Singapur, Carlsbad, Irvine, San Francisco | 1998 |
| RCA Records | Nueva York | 1901 |
| Real3D | Orlando | 1986 |
| Realty income | San Diego | 1969 |
| Red Digital Cinema Camera Company | Lake Forest | 2005 |
| Red Orb Entertainment | Novato | 1997 |
| Red Wing Shoes | Red Wing | 1905 |
| Redfin | Seattle | 2004 |
| Regeneron Pharmaceuticals | Eastview | 1988 |
| Remington Arms | Madison | 1816 |
| RhythmOne | San Francisco | 2004 |
| Richard Childress Racing | — | 1969 |
| Rite Aid | Filadelfia, Municipio de East Pennsboro (condado de Cumberland, Pensilvania) | 1962 |
| RKO Pictures | Manhattan | 23 de octubre de 1928 |
| Robinson Helicopter | Zamperini Field | 1973 |
| Rocketdyne | Los Ángeles | 1955 |
| Rockwell Collins | Cedar Rapids | 1933 |
| Rogers Locomotive and Machine Works | — | 1832 |
| Room to Read | San Francisco | 2000 |
| Rotten Tomatoes | San Francisco | 19 de agosto de 1998 |
| Rough Draft Studios | Glendale | 1990 |
| Roxio | Santa Clara | 2001 |
| RR Donnelley | Chicago | 1864 |
| RSA Security | Bedford | 1986 |
| Ryder | Coral Gables | 1933 |
| S&P Global | Rockefeller Center, Nueva York | — |
| S. C. Johnson & Son | Racine | 1886 |
| Saatchi & Saatchi | Nueva York | 1970 |
| Sanmina-SCI Corporation | San José | 1980 |
| Scholastic Corporation | Nueva York, Scholastic Building | 1920 |
| Schweizer Aircraft | Horseheads, Nueva York | 1939 |
| Scribd | San Francisco | marzo 2006 |
| SDI Media Group | Culver City | 1965 |