| Red Wing Shoes | Red Wing | 1905 |
| Remington Arms | Madison | 1816 |
| Rite Aid | Filadelfia, Municipio de East Pennsboro (condado de Cumberland, Pensilvania) | 1962 |
| Robinson Helicopter | Zamperini Field | 1973 |
| Ross Stores | Dublin | 1954 |
| Rough Draft Studios | Glendale | 1990 |
| RSA Security | Bedford | 1986 |
| S&P Global | Rockefeller Center, Nueva York | — |
| S. C. Johnson & Son | Racine | 1886 |
| SAS Institute | Cary | 1976 |
| Seagate | Cupertino | 1979 |
| Sealy Corporation | Trinity | 1881 |
| Sears Holdings Corporation | Hoffman Estates | 2005 |
| Shimmer Women Athletes | Illinois, Chicago, Berwyn | 6 de noviembre de 2005 |
| Shure Incorporated | Niles | 1925 |
| Siebel Systems | Austin | 1993 |
| Silver Lake | Menlo Park | 1999 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| SiRF | San José | 1995 |
| Six Flags | Arlington | 1961 |
| Smith & Wesson | Springfield | 1852 |
| SoundHound | Santa Clara | septiembre 2005 |
| Southern Company | Atlanta | 1945 |
| Spanx | Atlanta | 2000 |
| Speedway Motorsports | Concord | 1959 |
| Standard Oil | Ohio, Cleveland, Nueva York | 1890 |
| Starwood Hotels & Resorts Worldwide | White Plains | 1930 |
| Starz Entertainment | Santa Mónica | 28 de abril de 1997 |
| State Street Corporation | Boston | 1792 |
| Steak 'n Shake | Indianápolis | 1934 |
| Stratolaunch Systems | Montgomery, Seattle | 2011 |
| Substack | — | 29 de noviembre de 2017 |
| Subway | Milford | 28 de agosto de 1965 |
| Sunkist Growers | Los Ángeles | 29 de agosto de 1893 |
| Swift Engineering | San Clemente | 1983 |
| Sylvania Electric Products | — | 1942 |
| Synaptics | Santa Clara | 1986 |
| Synopsys | Mountain View | 1986 |
| T-Mobile US | Bellevue | 2001 |
| T. Rowe Price | Baltimore | 1937 |
| Taser International | Scottsdale | septiembre 1993 |
| Telltale Games | San Rafael | julio 2004 |
| Tenneco | Lake Forest | 1930 |
| TerraPower | Bellevue | 2008 |
| Tesla | Austin | 1 de julio de 2003 |
| Texaco | San Ramón | 1901 |
| The Cigna Group | Bloomfield | 1982 |
| The Hartford | Hartford, Connecticut | 1810 |